A review on synthetic investigation for quinoline- recent green approaches

Quinolines are a prominent heterocyclic motif and crucial building blocks in creating physiologically active compounds. Due to the fast development of novel medicines with quinoline nucleus, numerous research papers have been published short amount time. Therefore, comprehend present state nucleus medicinal chemistry science, it is necessary combine new information older data. So far, several traditional synthesis techniques reported literature synthesize this scaffold. Pfitzinger, Gould–Jacob, Friedlander, Skraup, Doebner–von Miller, Conrad–Limpach examples old synthetic methods. However, they need expensive demanding conditions, such as high temperature, use non-biodegradable chemical compounds degrade ecosystem, create irritation or harm pollutants, represent threat environment. processes difficult time-consuming apparatus set-up, resulting costs pollutants. As result, scientists presently developing innovative decrease chemicals, solvents, catalysts, which detrimental both humans we attempted shed light current review on various reactions produce quinolines their derivatives using green